DNA polymorphisms of apolipoprotein B and AI-CIII-AIV genes in a Brazilian population: a preliminary report
Braz. j. med. biol. res
; 29(10): 1269-74, Oct. 1996. tab
Article
en En
| LILACS
| ID: lil-186173
Biblioteca responsable:
BR1.1
RESUMO
Possible associations between coronary heart disease (CHD) and restriction fragment length polymorphisms (RFLPs) in the apo AI-CIII-AIV cluster and the apo B gene were investigated in a Brazilian population consisting of 46 patients with CHD and 24 individuals without evidence of CHD. A preliminary genetic analysis of SstI RFLP in the apo AI-CIII-AIV cluster showed a significantly higher frequency of the rare SstI allele (S2) in CHD patients as compared with controls. No significant differences were found in the frequencies of PstI RFLP in the apo AI-CIII-AIV cluster or XbaI and EcoRI RFLPs in the apo B gene between CHD patients and controls. Moreover, no association was seen between the RFLPs studied and myocardial infarction or plasma cholesterol or triglyceride levels.
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Bases de datos:
LILACS
Asunto principal:
Apolipoproteínas B
/
Polimorfismo Genético
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Apolipoproteína A-I
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Enfermedad Coronaria
Límite:
Adult
/
Aged
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Female
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Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1996
Tipo del documento:
Article
/
Project document