[Gemcitabine in advanced stage soft tissue sarcoma: a phase II study]. / Gemcitabina nei sarcomi dei tessuti molli in fase avanzata: studio di fase II.
Clin Ter
; 150(1): 17-20, 1999.
Article
en It
| MEDLINE
| ID: mdl-10367540
ABSTRACT
PURPOSE:
To assess the activity and toxicity of gemcitabine in locally advanced or metastatic soft tissue sarcoma patients (pts). PATIENTS ANDMETHODS:
Gemcitabine was administered on days 1, 8, 15 every 4 weeks at a dose of 1.000/1.250 mg/m2, respectively, in pretreated or not pretreated pts.RESULTS:
Eighteen pts entered this phase II trial; sixteen had been previously treated with anthracyclines and ifosfamide. A partial response was observed in a woman with fibrous malignant istocytoma, whereas in 7 pts the disease remained stable. Median time to progression was 4 months. The treatment was well tolerated. Grade 4 toxicity was not observed.CONCLUSIONS:
These results do not suggest that gemcitabine, in the dose and schedule used in this trial, may be of value in the treatment of soft tissue sarcomas.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Desoxicitidina
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
Idioma:
It
Revista:
Clin Ter
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia