Influence of haloperidol on the relationship of frontal lobe function to psychomotor poverty and disorganization syndromes.
Psychiatry Res
; 93(1): 33-9, 2000 Feb 14.
Article
en En
| MEDLINE
| ID: mdl-10699226
ABSTRACT
The aim of the study was to examine effects of haloperidol on the relationships between neuropsychological measures of frontal lobe functioning and the schizophrenia syndromes of psychomotor poverty and disorganization. Twenty-one participants with schizophrenia were initially evaluated when clinically stable and chronically treated with haloperidol, and 19 were evaluated again after a 3-week haloperidol-free period. Participants were evaluated with the Trail Making Test, the Wisconsin Card Sorting Test, the Purdue Pegboard, and psychiatric rating scales at each evaluation. There were significant correlations between schizophrenia syndromes and the tests sensitive to frontal lobe function when participants were medicated but not when drug-free. No significant changes in symptom severity or motor function occurred from the medication to the medication-free evaluation. The results indicate that haloperidol mediates the relationship between tests sensitive to frontal lobe function and the schizophrenia syndromes of psychomotor poverty and disorganization. This mediation effect was not attributable to changes in overall symptom severity or motor function.
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Bases de datos:
MEDLINE
Asunto principal:
Desempeño Psicomotor
/
Esquizofrenia
/
Psicología del Esquizofrénico
/
Antipsicóticos
/
Lóbulo Frontal
/
Haloperidol
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos