Complexity and dynamics of HIV-1 quasispecies.
J Biol Regul Homeost Agents
; 14(1): 4-6, 2000.
Article
en En
| MEDLINE
| ID: mdl-10763883
ABSTRACT
The human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins mediate virus entry into target cells by binding receptors of the cell membrane and fusing viral and cellular structures. In particular, recent crystallographic studies have clarified the complex role of the glycoprotein gp120 in the early phase of the infection. In this context the inter- and intra-host variability of the HIV-1 gp120 poses a major problem for the development of effective methods of immunization against this virus. In the present report, the relevant aspects emerging from the study of HIV-1 variability are addressed and several methodological approaches to evaluate HIV-1 diversity discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
Límite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia