Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice.
Surgery
; 128(6): 910-7, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11114623
ABSTRACT
BACKGROUND:
Endocrine allografts are an option for the treatment of endocrine failure.METHODS:
One lobe of the thyroid was transplanted under the kidney capsule.RESULTS:
C57BL/10 (H2(b)) thyroids were rejected in naive CBA (H2(k)) mice within 14 days after transplantation. When mice were treated with anti-CD4 monoclonal antibodies (mAb), all grafts survived for more than 60 days. The first grafts still survived after second C57BL/10 or Balb/c (H2(d)) thyroid grafts that were transplanted into the same recipients were rejected acutely, which suggests that the primary grafts were modified under anti-CD4 mAb treatment. To confirm this hypothesis, C57BL/10 thyroid grafts from anti-CD4 mAb-treated mice were retransplanted. All grafts survived in naive mice; this correlated with the overexpression of heme oxygenase-1 (HO-1) in the grafts. Next, an inhibitor of HO-1 (zinc protoporphyrin) or control compound (copper protoporphyrin) was injected intraperitoneally after transplantation of C57BL/10 thyroid grafts into the primary CBA recipients that had been treated with anti-CD4 mAb. The grafts in mice that had been treated with zinc protoporphyrin, but not copper protoporphyrin, were rejected when retransplanted to naive recipients.CONCLUSIONS:
Overexpression of HO-1 correlated with the protection of fully allogeneic thyroid grafts from rejection when retransplanted into naive recipients.
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Bases de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
/
Rechazo de Injerto
/
Hemo Oxigenasa (Desciclizante)
Límite:
Animals
Idioma:
En
Revista:
Surgery
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón