The correlation of TERT expression with c-myc expression in cervical cancer.
Cancer Lett
; 168(1): 45-50, 2001 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-11368876
ABSTRACT
Recently putative catalytic telomerase subunit was identified as telomerase reverse transcriptase (TERT). Several reports showed that TERT expression correlated with telomerase activity. It has also been found that c-myc can induce telomerase activation through TERT expression. We examined expression of TERT and c-myc and their correlation in cervical cancers by reverse transcription-polymerase chain reaction (RT-PCR). It was found that TERT and c-myc expression was observed mostly in malignancies and expression of c-myc was concordant for positivity and negativity with TERT. These results support recent studies that c-myc expression is closely associated with TERT and telomerase activity. c-myc up-regulation may play an important role in activation of TERT and telomerase.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
ARN
/
Neoplasias del Cuello Uterino
/
Proteínas Proto-Oncogénicas c-myc
/
Telomerasa
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón