Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.
Eur J Med Chem
; 36(4): 361-6, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11461761
ABSTRACT
Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED(50), <6 microg mL(-1)) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).
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Bases de datos:
MEDLINE
Asunto principal:
Clorambucilo
/
Antraquinonas
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2001
Tipo del documento:
Article