Effects of ENA713 and CHF2819, two anti-Alzheimer's disease drugs, on rat amino acid levels.
Brain Res
; 910(1-2): 182-6, 2001 Aug 10.
Article
en En
| MEDLINE
| ID: mdl-11489269
The effects of oral ENA713 and CHF2819 (0.5, 1.5 and 4.5 mg/kg), two novel acetylcholinesterase inhibitors, on extracellular concentrations of amino acids in rat hippocampus, were evaluated using in vivo microdialysis. ENA713, at 4.5 mg/kg, but not CHF2819, significantly decreased glutamate, taurine, arginine and citrulline levels, without affecting aspartate concentrations. These results suggest that the modulation of amino acidergic transmission could represent an additional mechanism of action in Alzheimer's disease for some acetylcholinesterase inhibitors.
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Bases de datos:
MEDLINE
Asunto principal:
Carbamatos
/
Inhibidores de la Colinesterasa
/
Aminoácidos Excitadores
/
Óxidos N-Cíclicos
/
Fenilcarbamatos
/
Enfermedad de Alzheimer
/
Hipocampo
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia