Treatment with irbesartan or atenolol improves endothelial function in essential hypertension.
J Hypertens
; 19(10): 1813-8, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11593101
ABSTRACT
OBJECTIVES:
To investigate if antihypertensive treatment could improve endothelium-dependent vasodilatation in hypertensive patients, and whether the angiotensin II subtype-1 (AT1)-receptor antagonist irbesartan and the beta1-receptor antagonist atenolol would differ in this respect. SUBJECTS ANDMETHODS:
Thirty-four patients (28 men and six women) with mild-to-moderate essential hypertension (diastolic blood pressure 90-120 mmHg) were randomized to once daily 150-300 mg irbesartan or 50-100 mg atenolol in a double-blind fashion, preceded by a placebo run-in period. Forearm blood flow (FBF) was assessed by venous occlusion plethysmography during local intra-arterial infusions of methacholine and sodium nitroprusside, to evaluate endothelium-dependent and endothelium-independent vasodilatation, respectively. Measurements of FBF were undertaken at the end of the run-in placebo period and repeated after 3 months of active antihypertensive treatment.RESULTS:
Irbesartan and atenolol induced a similar decline in blood pressure (from 171/107 to 158/98 mmHg, P < 0.05), and improved endothelium-dependent vasodilatation (e.g. an increase in FBF response to 4 microg/min methacholine from 325 +/- 29% to 411 +/- 41%, P < 0.05), with no difference between the two study drugs. No significant changes in endothelium-independent vasodilatation were induced by irbesartan or by atenolol.CONCLUSIONS:
The present study shows that 3 months of antihypertensive therapy with irbesartan or atenolol improves endothelium-dependent vasodilatation.
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Bases de datos:
MEDLINE
Asunto principal:
Atenolol
/
Tetrazoles
/
Compuestos de Bifenilo
/
Endotelio Vascular
/
Antagonistas Adrenérgicos beta
/
Hipertensión
/
Antihipertensivos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Hypertens
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia