Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys.
Synapse
; 44(4): 246-51, 2002 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-11984859
The effect of tetrabenazine (TBZ) pretreatment on the striatal uptake of exogenous L-DOPA in vivo was assessed noninvasively in rhesus monkeys by positron emission tomography (PET) using the tracer [(18)F]-FluoroDOPA (FDOPA). Paired studies were done comparing baseline vs. TBZ treatment on the uptake of FDOPA, a measure of aromatic L-amino acid decarboxylase (AAAD) activity. Results show increased AAAD activity with TBZ treatment. These results suggest that the action of TBZ as a dopamine antagonist dominates more than its expected action as a potent vesicular monoamine transporter (VMAT2) inhibitor. Results also showed diminished responsivity of AAAD to TBZ challenge in aged monkey brain.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Tetrabenazina
/
Neuropéptidos
/
Envejecimiento
/
Dopaminérgicos
/
Dihidroxifenilalanina
/
Levodopa
/
Neostriado
/
Inhibidores de Captación Adrenérgica
Límite:
Animals
Idioma:
En
Revista:
Synapse
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos