[Effect of non-steroid anti-inflammatory and glucocorticoid agents on development of gastrointestinal lesions in patients with rheumatic diseases]. / Vliianie nesteroidnykh protivovospalitel'nykh i gliukokortikoidnykh preparatov na razvitie porazhenii pishchevaritel'nogo kanala u bol'nykh s revmatologicheskimi zabolevaniiami.
Lik Sprava
; (2): 142-3, 2002.
Article
en Ru
| MEDLINE
| ID: mdl-12073250
ABSTRACT
A comparative evaluation was done of frequency and severity of upper gastrointestinal mucosal lesions in patients taking nonsteroid antiinflammatory drugs (NSAID) and glucocorticosteroids (GCS). A total of 65 rheumatic patients examined endoscopically entered the study. The patients were divided into three groups. Group I comprised 12 patients placed on GCS only, group II was 35 patients on NSAID, group III was 18 patients who received NSAID plus GCS. Gastropathies were diagnosed in 25%, 45.7%, 44.4% of patients in groups I, II, and III respectively. Group II patients had a higher incidence of serious afflictions. As far as the gastrointestinal mucosa is concerned, GCS have been shown to be superior to NSAID. A combined use of NSAID + GCS, unlike NSAID alone, has not been found to increase the risk of development of gastropathy.
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Bases de datos:
MEDLINE
Asunto principal:
Úlcera Péptica
/
Antiinflamatorios no Esteroideos
/
Enfermedades Reumáticas
/
Glucocorticoides
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Lik Sprava
Asunto de la revista:
MEDICINA
Año:
2002
Tipo del documento:
Article