Interspecies comparison of the oral absorption of itraconazole in laboratory animals.
Arch Pharm Res
; 25(3): 387-91, 2002 Jun.
Article
en En
| MEDLINE
| ID: mdl-12135115
ABSTRACT
The oral absorption and disposition of itraconazole were studied in rats, rabbits and dogs. Serum levels of itraconazole and its active metabolite, hydroxyitraconazole, were determined by a validated HPLC method. The absorption of itraconazole was relatively rapid in rats and dogs but was slower in rabbits. The terminal elimination half-life (T 1/2lambda(z)), time to the peak concentration (Tmax), dose and weight normalized area under the curve (AUC) and the peak concentration (Cmax) of itraconazole found in the dog were comparable to those reported in humans. As in humans, the metabolite to parent drug AUC ratios in rats and dogs were greater than unity but was less in rabbits. The dog appears to be an appropriate animal model while the rat, not the rabbit, may be used as an alternative animal model in predicting the oral absorption of itraconazole in humans.
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Bases de datos:
MEDLINE
Asunto principal:
Itraconazol
/
Antifúngicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Año:
2002
Tipo del documento:
Article