Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection.
J Parasitol
; 88(4): 797-9, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12197135
ABSTRACT
The role of T lymphocyte subpopulations in the protection against intraperitoneal (i.p.) and peroral Encephalitozoon cuniculi infections was compared in adoptive-transfer experiments using severe combined immunodeficient mice. Whereas CD8+ T cell-depleted, but not CD4+ T cell-depleted, BALB/c splenocytes failed to protect the mice against i.p. infection, only SCID mice reconstituted with both CD4+ T lymphocyte- and CD8+ T lymphocyte-depleted splenocytes succumbed to peroral infection. The results indicate that whereas CD8+ T cells are critical for the protection against an i.p. E. cuniculi infection, both CD4+ and CD8+ T lymphocyte subpopulations play a substantive protective role in a peroral infection, i.e., natural route of infection.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Encefalitozoonosis
/
Encephalitozoon cuniculi
/
Linfocitos T CD8-positivos
Límite:
Animals
Idioma:
En
Revista:
J Parasitol
Año:
2002
Tipo del documento:
Article
País de afiliación:
República Checa