Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function.
Liver Transpl
; 9(1): 40-8, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12514772
ABSTRACT
Orthotopic liver transplantation (OLT) is a frequent option in the treatment of liver diseases. During the cold ischemia period of the donor liver, there is an accumulation of metabolites that are potent inhibitors of the cytokine-inducible and endothelial nitric oxide synthase isoenzymes. We identified the presence of L-N-monomethylarginine and asymmetric dimethylarginine (ADMA) as the main inhibitors by means of analytic high-pressure liquid chromatography and mass spectrometry techniques. An average ADMA concentration of 450 micromol/L was measured in the preservation medium of donor livers with poor outcomes after OLT. A statistically significant relationship was observed between the concentration of methylated arginine derivatives in the graft and liver function after OLT. These data suggest that measurement of methylated arginine, released after liver protein catabolism, might provide an indication of functional status of the liver that can help the development of strategies intended to improve graft viability.
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Bases de datos:
MEDLINE
Asunto principal:
Arginina
/
Trasplante de Hígado
/
Óxido Nítrico Sintasa
Límite:
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Liver Transpl
Asunto de la revista:
GASTROENTEROLOGIA
/
TRANSPLANTE
Año:
2003
Tipo del documento:
Article
País de afiliación:
España