Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations.
Am J Hypertens
; 16(2): 154-7, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12559685
ABSTRACT
We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak >1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score >1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Genoma Humano
/
Población Negra
/
Población Blanca
/
Hipertensión
/
Ligamiento Genético
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Hypertens
Asunto de la revista:
ANGIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos