Risk of fracture and treatment to prevent osteoporosis-related fracture in postmenopausal women. A review.
J Reprod Med
; 48(6): 425-34, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12856513
ABSTRACT
OBJECTIVE:
To review the antifracture efficacy of pharmacologic therapy approved by the U.S. Food and Drug Administration for the treatment of postmenopausal osteoporosis. STUDYDESIGN:
For this literature review, published trials of antiresorptive therapy with the bisphosphonates risedronate and alendronate, the selective estrogen receptor modulator raloxifene and calcitonin were reviewed; hormone replacement therapy was not included as this modality is not indicated for treatment of osteoporosis.RESULTS:
In controlled trials of postmenopausal women with osteoporosis, risedronate reduced the incidence of clinically evident vertebral fracture after 6 months of therapy and radiographically detected vertebral and nonvertebral fracture after 1 year. In similar trials, alendronate also reduced the risk of clinical vertebral fractures in 1 year. Risedronate and alendronate were both well tolerated, but some trials of alendronate were closed to women with recent upper gastrointestinal disease. In a large, controlled trial, raloxifene demonstrated a significant reduction in the risk of clinical vertebral fracture but not in the risk of nonvertebral fracture. Raloxifene is also associated with a 3-fold increased risk of thromboembolism. Calcitonin reduced the incidence of vertebral fracture, but there are no conclusive data on prevention of nonvertebral fracture.CONCLUSION:
Antiresorptive therapy can reduce the risk of osteoporotic vertebral fracture. The bisphosphonates are also effective in reducing the risk of hip fracture in women with osteoporosis.
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Bases de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Calcitonina
/
Posmenopausia
/
Alendronato
/
Clorhidrato de Raloxifeno
/
Difosfonatos
/
Fracturas Óseas
/
Antagonistas de Estrógenos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Reprod Med
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos