Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7.
Dev Cell
; 5(3): 475-86, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12967566
ABSTRACT
ErbB-2/HER2 drives epithelial malignancies by forming heterodimers with growth factor receptors. The primordial invertebrate receptor is sorted to the basolateral epithelial surface by binding of the PDZ domain of Lin-7 to the receptor's tail. We show that all four human ErbBs are basolaterally expressed, even when the tail motif is absent. Mutagenesis of hLin-7 unveiled a second domain, KID, that binds to the kinase region of ErbBs. The PDZ interaction mediates stabilization of ErbB-2 at the basolateral surface. On the other hand, binding of KID is involved in initial delivery to the basolateral surface, and in its absence, unprocessed ErbB-2 molecules are diverted to the apical surface. Hence, distinct domains of Lin-7 regulate receptor delivery to and maintenance at the basolateral surface of epithelia.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Polaridad Celular
/
Receptor ErbB-2
/
Proteínas de Caenorhabditis elegans
/
Epitelio
/
Proteínas de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Cell
Asunto de la revista:
EMBRIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Israel