Cascade cyclizations and couplings involving nickel enolates.
J Am Chem Soc
; 125(44): 13481-5, 2003 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-14583044
ABSTRACT
A new strategy for effecting cascade cyclization processes using nickel enolates has been developed. Nickel enolates may be cleanly generated by the oxidative cyclization of an enal and alkyne with Ni(0), and the resulting enolate may be functionalized by a variety of alkylation processes. Partially and fully intramolecular versions of the process allow the rapid synthesis of complex polycyclics from simple achiral, acyclic precursors.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos