Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells.
J Immunol
; 171(12): 6549-55, 2003 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-14662856
ABSTRACT
Inflammation plays an important role in ischemic stroke and in humans IL-10 may have a beneficial effect in stroke. We mucosally administered myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide to C57BL/6 mice before middle cerebral artery occlusion (MCAO) to induce an anti-inflammatory T cell response directed at CNS myelin. Nasal and oral administration of MOG(35-55) peptide decreased ischemic infarct size at 24 and 72 h after MCAO surgery. Nasal MOG(35-55) peptide was most efficacious and reduced infarct size by 70% at 24 h and by 50% at 72 h (p
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Bases de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Vacunas
/
Glicoproteínas
/
Linfocitos T CD4-Positivos
/
Isquemia Encefálica
/
Interleucina-10
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos