The impact of self-tolerance on the polyclonal CD8+ T cell repertoire.
J Immunol
; 172(4): 2324-31, 2004 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-14764701
ABSTRACT
TCRs possess considerable cross-reactivity toward structurally related Ags. Because the signaling threshold for negative selection is lower than that required for activation of mature T cells, the question arises as to which extent thymic deletion of self-specific T cells affects T cell responsiveness toward foreign peptides. In this study we show, in three different mouse models systems, that the polyclonal CD8(+) T cell repertoire has a marked ability to react against the majority of Ags related to self despite self-tolerance, even in cases where self and foreign differ only marginally at a single TCR-contact residue. Thus, while individual T cells are markedly cross-reactive, the ability to distinguish between closely related Ags is introduced at the polyclonal T cell level.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Autotolerancia
/
Linfocitos T CD8-positivos
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Países Bajos