Human embryonic stem cells: a potential source for cellular therapy.
Am J Transplant
; 4 Suppl 6: 51-7, 2004.
Article
en En
| MEDLINE
| ID: mdl-14871274
ABSTRACT
Many degenerative human diseases reflect damage to cells that are not normally repaired or replaced, such as diabetes, Parkinson's disease, hepatic failure and congestive heart failure. Preliminary studies in animals and humans have suggested that these diseases may be treatable by transplantation of healthy cells. Such cells may be obtained by in vitro culture of embryonic stem cells, which are capable of differentiating into many cell types. This review discusses applicative approaches for the derivation, maintenance and safety of human embryonic stem (hES) cells as well as ethical concerns surrounding their possible source for cellular therapy. hES cells offer broad application in cellular therapy; however, this review specifically emphasizes on cardiovascular repair, generation and characterization of hES cell-derived cardiomyocytes, vascular progenitors and differentiation of derivatives.
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Bases de datos:
MEDLINE
Asunto principal:
Sistema Cardiovascular
/
Miocitos Cardíacos
/
Células Madre Pluripotentes
/
Trasplante de Células Madre
/
Cardiomiopatías
Límite:
Humans
Idioma:
En
Revista:
Am J Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2004
Tipo del documento:
Article
País de afiliación:
Israel