Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.
Bioorg Med Chem Lett
; 14(10): 2551-4, 2004 May 17.
Article
en En
| MEDLINE
| ID: mdl-15109649
ABSTRACT
A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathiin analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ER alpha over ER beta, but were less potent than the original lead compound 1a in the inhibition of estradiol-driven uterine proliferation.
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Bases de datos:
MEDLINE
Asunto principal:
Receptores de Estrógenos
/
Moduladores Selectivos de los Receptores de Estrógeno
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos