Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat.
Peptides
; 25(6): 967-74, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15203243
ABSTRACT
We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese fa/fa rats. GALP mRNA in the ARC in fa/fa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in fa/fa rats was significantly increased in 18-week-old compared to lean Fa/? rats. Insulin treatment in hyperglycemic fa/fa rats partially reversed those changes. These results suggest that the GALP gene expression in fa/fa rats might be regulated in part by leptin-independent mechanisms.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Neurohipófisis
/
Núcleo Arqueado del Hipotálamo
/
Péptido Similar a Galanina
/
Obesidad
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón