Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.
Antimicrob Agents Chemother
; 48(7): 2760-5, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15215146
ABSTRACT
Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-beta-d-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Bencimidazoles
/
Citomegalovirus
/
Nucleósidos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos