Metabolomic analysis of molecular species of phospholipids from normotensive and preeclamptic human placenta electrospray ionization mass spectrometry.
Front Biosci
; 9: 3167-75, 2004 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-15353347
ABSTRACT
Electrospray ionization mass spectrometry (ESI/MS) is a highly sensitive, fast and powerful technique for the metabolite and metabolomic analysis of mixtures of lipids in a biological extract. We have exploited this technique to identify and characterize various phospholipids present in the placenta of preeclamptic and normal pregnant women. Multiple major molecular species can be detected in each phospholipid class have arachidonic acid as major fatty acid constituent. There is no remarkable difference in the molecular composition in each of these phospholipids in both the extracts. However, there seems to be lower amounts of the plasmenyl phosphatidylethanolamine and greater amounts of free fatty acids in preeclamptic placenta.
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Bases de datos:
MEDLINE
Asunto principal:
Placenta
/
Preeclampsia
/
Espectrometría de Masa por Ionización de Electrospray
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Front Biosci
Asunto de la revista:
BIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos