A novel human G protein-coupled receptor is over-expressed in prostate cancer.
Genet Mol Res
; 3(4): 521-31, 2004 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-15688318
ABSTRACT
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily. The gene expression pattern of this receptor is restricted in normal tissues it is confined to the nervous system and testis, but we also detected gene expression in several tumor types, most notably prostate cancer, suggesting a potential role for this gene as a marker for this disease.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Regulación Neoplásica de la Expresión Génica
/
Receptores Acoplados a Proteínas G
/
Proteínas de Neoplasias
Límite:
Humans
/
Male
Idioma:
En
Revista:
Genet Mol Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Brasil