Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury.
Curr Vasc Pharmacol
; 3(3): 215-20, 2005 Jul.
Article
en En
| MEDLINE
| ID: mdl-16026318
ABSTRACT
Ischemia and reperfusion injury leads to a complex pathophysiological process, which in turn results in the generation of free radicals. Peroxynitrite, a highly reactive species causes DNA single strand breaks, which activates the nuclear enzyme, poly (ADP-ribose) polymerase (PARP). The activation of PARP leads to an energy consuming inefficient repair cycle with subsequent depletion of NAD(+) and ATP pools and necrotic cell death. The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión Miocárdica
/
Poli(ADP-Ribosa) Polimerasas
/
Ácido Peroxinitroso
/
Especies de Nitrógeno Reactivo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Vasc Pharmacol
Asunto de la revista:
ANGIOLOGIA
/
FARMACOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Alemania