The role of sex hormones in the kinetics of chondrocytes in the growth plate. A study in the rabbit.
J Bone Joint Surg Br
; 87(9): 1278-84, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16129759
ABSTRACT
Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age. Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.
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Bases de datos:
MEDLINE
Asunto principal:
Testosterona
/
Condrocitos
/
Placa de Crecimiento
Límite:
Animals
Idioma:
En
Revista:
J Bone Joint Surg Br
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón