Brn-3a neuronal transcription factor functional expression in human prostate cancer.
Prostate Cancer Prostatic Dis
; 9(1): 83-91, 2006.
Article
en En
| MEDLINE
| ID: mdl-16276351
ABSTRACT
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Factor de Transcripción Brn-3A
Límite:
Humans
/
Male
Idioma:
En
Revista:
Prostate Cancer Prostatic Dis
Asunto de la revista:
ENDOCRINOLOGIA
/
NEOPLASIAS
/
UROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido