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[Assessment of goserelin treatment in adjuvant therapy for premenopausal patients with breast cancer in Japan-zoladex breast cancer study group trial-B].
Gan To Kagaku Ryoho ; 32(13): 2071-7, 2005 Dec.
Article en Ja | MEDLINE | ID: mdl-16352931
OBJECTIVE: Goserelin (GOS) therapy in an adjuvant setting for estrogen receptor(ER)-positive premenopausal patients with breast cancer was assessed in a randomised comparative study. METHODS: ER positive premenopausal patients with n + or n 0 and T > or = 3 cm received tamoxifen (TAM) 20 mg/day, GOS 3.6 mg/4 weeks or GOS + TAM for 2 years, and the clinical efficacy and safety of these regimens were assessed. RESULTS: In the data analysis of total 207 patients, hazard ratios of disease free survival (DFS) and overall survival (OS) in the GOS group compared to the TAM group were 0.87 and 2.10,respectively. The incidence of adverse drug reactions was similar (42-55%) in all three groups. Since the number of patients in this study did not reach the target number, the efficacy could not be assessed from a statistical aspect. Therefore,meta-analysis with similar foreign studies(ZIPP) was implemented. The results of meta-analysis showed that the hazard ratios of DFS and OS in the GOS group compared to the non-GOS group were 0.83 and 0.85, respectively. CONCLUSION: Although the analysis of 207 patients did not show any statistically significant difference between each of the treatment groups, the results of meta-analysis showed a significant prolongation of DFS in the GOS group. Also high tolerability of GOS was suggested. From these results, GOS was considered highly useful in adjuvant therapy for ER-positive premenopausal patients with breast cancer.
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Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Goserelina / Premenopausia / Antineoplásicos Hormonales Tipo de estudio: Clinical_trials Límite: Adult / Humans / Middle aged Idioma: Ja Revista: Gan To Kagaku Ryoho Año: 2005 Tipo del documento: Article
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Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Goserelina / Premenopausia / Antineoplásicos Hormonales Tipo de estudio: Clinical_trials Límite: Adult / Humans / Middle aged Idioma: Ja Revista: Gan To Kagaku Ryoho Año: 2005 Tipo del documento: Article