The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.
Bioorg Med Chem Lett
; 16(8): 2209-12, 2006 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-16458510
ABSTRACT
A series of competitive, reversible cathepsin S (CatS) inhibitors was investigated. An earlier disclosure detailed the discovery of the 4-(2-keto-1-benzimidazolinyl)-piperidin-1-yl moiety as an effective replacement for the 4-arylpiperazin-1-yl group found in our screening hit. Continued investigation into replacements for the 4-aryl piperazine resulted in the identification of potentially useful CatS inhibitors with enzymatic and cellular activity similar to that of JNJ 10329670 as disclosed in a previous publication.
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Bases de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Compuestos Bicíclicos con Puentes
/
Catepsinas
/
Inhibidores Enzimáticos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos