Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation.
J Perinatol
; 26(3): 147-53, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16467857
ABSTRACT
OBJECTIVE:
To examine the consequences of antenatal betamethasone (AB) exposure on postnatal stress regulation. STUDYDESIGN:
Fourteen AB exposed infants born at 28-30 weeks' gestation were assessed in the NICU during postnatal week 1 and at 34 weeks postconception. Nine infants born at 34 weeks gestation without AB treatment were evaluated as a postconceptional age comparison group. Salivary cortisol, heart rate, and behavior were measured at baseline and in response to a heelstick blood draw.RESULTS:
Repeated measures ANOVAs revealed that both groups displayed an increase in heart rate and behavioral distress in response to the stressor. The cortisol response, however, was blunted in AB-treated infants at both assessments.CONCLUSION:
AB treatment has consequences for hypothalamic-pituitary-adrenal (HPA) axis regulation that persist for at least four to six weeks after birth, indicating that studies of long-term effects are warranted.
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Bases de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
/
Efectos Tardíos de la Exposición Prenatal
/
Recien Nacido Prematuro
/
Betametasona
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Perinatol
Asunto de la revista:
PERINATOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos