The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Dev Cell
; 10(3): 397-405, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16516842
ABSTRACT
Endocrine pancreatic beta cells require endothelial signals for their differentiation and function. However, the molecular basis for such signals remains unknown. Here, we show that beta cells, in contrast to the exocrine pancreatic cells, do not form a basement membrane. Instead, by using VEGF-A, they attract endothelial cells, which form capillaries with a vascular basement membrane next to the beta cells. We have identified laminins, among other vascular basement membrane proteins, as endothelial signals, which promote insulin gene expression and proliferation in beta cells. We further demonstrate that beta1-integrin is required for the beta cell response to the laminins. The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required.
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Bases de datos:
MEDLINE
Asunto principal:
Membrana Basal
/
Vasos Sanguíneos
/
Transducción de Señal
/
Regulación de la Expresión Génica
/
Células Secretoras de Insulina
/
Insulina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Dev Cell
Asunto de la revista:
EMBRIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Alemania