Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells.
Haematologica
; 91(3): 422-4, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16531271
This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia. E2A gene rearrangement and E2A-HLF transcript and protein expression were determined using conventional cytogenetics, fluorescent in situ hybridization, reverse transcriptase polymerase chain reaction and Western blotting in leukemic cells from three patients.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Translocación Genética
/
Cromosomas Humanos Par 17
/
Cromosomas Humanos Par 19
/
Proteínas de Fusión Oncogénica
/
Hibridación Fluorescente in Situ
/
Proteínas de Unión al ADN
/
Fusión Génica
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Haematologica
Año:
2006
Tipo del documento:
Article