Identification of a site in glutamate receptor subunits that controls calcium permeability.
Science
; 253(5023): 1028-31, 1991 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-1653450
ABSTRACT
The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the brain. A family of genes encoding subunits of the non-N-methyl-D-aspartate (non-NMDA) type of glutamate receptor has been cloned. Some combinations of these subunits assemble into receptors with a substantial permeability to calcium, whereas others do not. To investigate the structural features that control ion permeation through these ligand-gated channels, mutant receptor subunits with single-amino acid changes were constructed. Mutation of a certain amino acid that results in a net charge change (from glutamine to arginine or vice versa) alters both the current-voltage relation and the calcium permeability of non-NMDA receptors. A site has thus been identified that regulates the permeation properties of these glutamate receptors.
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Bases de datos:
MEDLINE
Asunto principal:
Permeabilidad de la Membrana Celular
/
Calcio
/
Receptores de N-Metil-D-Aspartato
/
Receptores de Neurotransmisores
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1991
Tipo del documento:
Article