Inhibition by somatostatin of ACTH secretion in Nelson's syndrome.
J Clin Endocrinol Metab
; 40(6): 1125-7, 1975 Jun.
Article
en En
| MEDLINE
| ID: mdl-166089
ABSTRACT
Somatostatin (GHIF), when administered as a 1-hr infusion (500 mug/hr) to 5 patients with Nelson's Syndrome;resulted in a sustained, progressive fall in plasma ACTH in each patient to 40% to 71% of basal values with a return toward initail levels after cessation of the infusion. The meanreduction in plasma ADTH was 48% (p less than 0.005). These finding suggest that GHIF receptors not fuctional or present in normal pituitary tissue are present in ACTH-producing pituitary tumors.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Hipofisarias
/
Somatostatina
/
Adenoma
/
Hormona Adrenocorticotrópica
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
1975
Tipo del documento:
Article