Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.
Arterioscler Thromb Vasc Biol
; 26(7): 1613-8, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16690874
ABSTRACT
OBJECTIVE:
Identify gene variants associated with early-onset myocardial infarction (MI). METHODS ANDRESULTS:
We tested 11 647 single-nucleotide polymorphisms (SNPs) for association with early-onset MI in a case-control study (study 1 200 cases, 262 controls). To reduce the number of false positives among the 666 SNPs that were nominally associated with early-onset MI (P<0.05) in study 1, we tested these SNPs in study 2 (434 cases, 504 controls). We found that 8 of the 666 SNPs were associated with early-onset MI in study 2 (P<0.05) and had the same risk alleles as in study 1. These 8 SNPs were then tested for association with early-onset MI in study 3 (187 cases, 434 controls). We found that a VAMP8 variant (P = 0.025; odds ratio [OR], 1.75; CI, 1.17 to 2.62) and an HNRPUL1 variant (P = 0.0043; OR, 1.92; CI, 1.28 to 2.86) were associated with early-onset MI (nominal P<0.05; false discovery rate <10%) and had the same risk alleles in all 3 studies.CONCLUSIONS:
Variants in 2 genes were associated with early-onset MI VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. The identification of these variants could improve understanding of disease mechanisms and suggest novel drug targets.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Variación Genética
/
Proteínas Nucleares
/
Ribonucleoproteínas Nucleares Heterogéneas
/
Proteínas R-SNARE
/
Infarto del Miocardio
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Asunto de la revista:
ANGIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos