Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Science
; 312(5779): 1530-3, 2006 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-16763152
ABSTRACT
Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
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Síndrome de Inmunodeficiencia Adquirida del Simio
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Virus de la Inmunodeficiencia de los Simios
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Vacunas contra el SIDAS
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Vacunas de ADN
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Memoria Inmunológica
Límite:
Animals
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Humans
Idioma:
En
Revista:
Science
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos