Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.
Hum Mol Genet
; 15(19): 2880-7, 2006 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-16923796
ABSTRACT
In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1. Previous studies have shown that MICA and MICB are expressed on the surface of cells in response to infection, where they are recognized by the NKG2D receptor on gammadelta T cells, CD8+ alphabeta T cells and natural killer cells, all of which contribute to defense against mycobacteria. The MICA*5A5.1 allele, associated here with leprosy susceptibility, encodes a protein lacking a cytoplasmic tail providing a possible mechanism for defective immune surveillance against mycobacteria.
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Bases de datos:
MEDLINE
Asunto principal:
Genes MHC Clase I
/
Antígenos de Histocompatibilidad Clase I
/
Lepra
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Hum Mol Genet
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido