MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.
Haematologica
; 91(9): 1287-8, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16956839
ABSTRACT
MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Proteínas de Fusión Oncogénica
Límite:
Female
/
Humans
/
Infant
Idioma:
En
Revista:
Haematologica
Año:
2006
Tipo del documento:
Article