Mitochondrial electron transport chain activity is not involved in ultraviolet A (UVA)-induced cell death.
Free Radic Biol Med
; 42(4): 499-509, 2007 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-17275682
Ultraviolet A (UVA), the long wavelength part of the sun's ultraviolet radiation, elicits its harmful effects through production of reactive oxygen species. In this study, we have tested the hypothesis that the mitochondrial electron transport chain, the main source of reactive oxygen species in cells, importantly contributes to UVA-induced cell damage. Model cell lines completely lacking a mitochondrial electron transport chain (rho(0)-cells) were not protected against UVA-induced cell death. Also, primary human fibroblasts and keratinocytes with induced depletion of electron transport chain activity were not better protected against UVA-induced cell death. On the other hand, diphenyleneiodonium and resiniferatoxin, inhibitors of plasma membrane oxidases, protected primary human fibroblasts against UVA, as potently as the lipid peroxidation chain breaker Trolox. These data indicate that plasma membrane electron transport systems, but not the mitochondrial electron transport chain, play a major role in UVA-induced cell death.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Rayos Ultravioleta
/
Muerte Celular
/
Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
Free Radic Biol Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania