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In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik.
Wu, Lin-Lin; Yang, Xin-Bo; Huang, Zheng-Ming; Liu, He-Zhi; Wu, Guang-Xia.
Afiliación
  • Wu LL; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Acta Pharmacol Sin ; 28(3): 404-9, 2007 Mar.
Article en En | MEDLINE | ID: mdl-17303004
AIM: To assess the anti-hepatitis B virus (HBV) effect of hyperoside extracted from Abelmoschus manihot (L) medik. METHODS: The human hepatoma Hep G2.2.15 cell culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo and in vitro models to evaluate the anti-HBV effects. RESULTS: In the cell model, the 50% toxic concentration of hyperoside was 0.115 g/L; the maximum nontoxic concentration was 0.05 g/L. On the maximum nontoxic concentrations, the inhibition rates of hyperoside on HBeAg and HBsAg in the 2.2.15 cells were 86.41% and 82.27% on d 8, respectively. In the DHBV infection model, the DHBV-DNA levels decreased significantly in the treatment of 0.05 g x kg(-1 ) x d(-1 ) and 0.10 g x kg(-1) x d(-1) dosage groups of hyperoside (P<0.01). The inhibition of the peak of viremia was at the maximum at the dose of 0.10 g x kg(-1 ) x d(-1) and reached 60.79% on d 10 and 69.78% on d 13, respectively. CONCLUSION: These results suggested that hyperoside is a strong inhibitor of HBsAg and HBeAg secretion in 2.2.15 cells and DHBV-DNA levels in the HBV-infected duck model.
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Bases de datos: MEDLINE Asunto principal: Antivirales / Quercetina / Abelmoschus Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2007 Tipo del documento: Article País de afiliación: China
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Bases de datos: MEDLINE Asunto principal: Antivirales / Quercetina / Abelmoschus Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2007 Tipo del documento: Article País de afiliación: China