Elevated rates of sister chromatid exchange at chromosome ends.
PLoS Genet
; 3(2): e32, 2007 Feb 23.
Article
en En
| MEDLINE
| ID: mdl-17319749
ABSTRACT
Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Intercambio de Cromátides Hermanas
/
Telómero
Límite:
Humans
Idioma:
En
Revista:
PLoS Genet
Asunto de la revista:
GENETICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos