[Complex analysis of prognostic factors in chronic lymphocytic leukemia]. / Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában.
Orv Hetil
; 148(16): 737-43, 2007 Apr 22.
Article
en Hu
| MEDLINE
| ID: mdl-17437950
ABSTRACT
INTRODUCTION:
Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival.AIMS:
The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.METHODS:
The mutation status of the IgH gene was evaluated in 160 cases.RESULTS:
In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.CONCLUSIONS:
The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
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Bases de datos:
MEDLINE
Asunto principal:
Trisomía
/
Reordenamiento Génico
/
Leucemia Linfocítica Crónica de Células B
/
Eliminación de Gen
/
Genes de las Cadenas Pesadas de las Inmunoglobulinas
/
Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Hu
Revista:
Orv Hetil
Año:
2007
Tipo del documento:
Article