Atrial natriuretic peptide (ANP) gene promoter variant and increased susceptibility to early development of hypertension in humans.
J Hum Hypertens
; 21(10): 822-4, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17525707
Previous evidence supports a role of atrial natriuretic peptide (ANP) as a candidate gene for hypertension. We characterized an ANP gene promoter variant, which has been associated with lower peptide levels, in a sample of young male subjects from Southern Italy (n=395, mean age=35.2+/-2 years) followed up for 28 years. In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.
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Bases de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Presión Sanguínea
/
Factor Natriurético Atrial
/
Predisposición Genética a la Enfermedad
/
Hipertensión
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Hum Hypertens
Asunto de la revista:
ANGIOLOGIA
Año:
2007
Tipo del documento:
Article