Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.
Antivir Ther
; 12(4): 571-6, 2007.
Article
en En
| MEDLINE
| ID: mdl-17668567
ABSTRACT
Influenza A viruses are responsible for significant morbidity and mortality after bone marrow transplantation. Here we report failure of inhaled zanamivir treatment in a bone-marrow transplant recipient with pneumonia caused by an influenza A (H1N1) virus, although the influenza viruses isolated from bronchoalveolar lavages before and after treatment were clearly found to be sensitive to zanamivir using cell-based and enzymatic assays. Subsequent oral treatment with oseltamivir allowed complete recovery. Poor bioavailability of zanamivir in the peripheral lungs might have been limiting treatment efficacy in such an immunocompromised patient.
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Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Neumonía Viral
/
Trasplante de Médula Ósea
/
Gripe Humana
/
Subtipo H1N1 del Virus de la Influenza A
/
Zanamivir
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Antivir Ther
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
/
VIROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia