Serum zinc and pneumonia in nursing home elderly.
Am J Clin Nutr
; 86(4): 1167-73, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17921398
BACKGROUND: Zinc plays an important role in immune function. The association between serum zinc and pneumonia in the elderly has not been studied. OBJECTIVE: The objective was to determine whether serum zinc concentrations in nursing home elderly are associated with the incidence and duration of pneumonia, total and duration of antibiotic use, and pneumonia-associated and all-cause mortality. DESIGN: This observational study was conducted in residents from 33 nursing homes in Boston, MA, who participated in a 1-y randomized, double-blind, and placebo-controlled vitamin E supplementation trial; all were given daily doses of 50% of the recommended dietary allowance of essential vitamins and minerals, including zinc. Participants with baseline (n = 578) or final (n = 420) serum zinc concentrations were categorized as having low (<70 microg/dL) or normal (>or=70 microg/dL) serum zinc concentrations. Outcome measures included the incidence and number of days with pneumonia, number of new antibiotic prescriptions, days of antibiotic use, death due to pneumonia, and all-cause mortality. RESULTS: Compared with subjects with low zinc concentrations, subjects with normal final serum zinc concentrations had a lower incidence of pneumonia, fewer (by almost 50%) new antibiotic prescriptions, a shorter duration of pneumonia, and fewer days of antibiotic use (3.9 d compared with 2.6 d) (P
Asunto(s)
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neumonía
/
Vitamina E
/
Zinc
/
Hogares para Ancianos
/
Casas de Salud
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neumonía
/
Vitamina E
/
Zinc
/
Hogares para Ancianos
/
Casas de Salud
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos