Structure and mechanics of integrin-based cell adhesion.
Curr Opin Cell Biol
; 19(5): 495-507, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17928215
ABSTRACT
Integrins are alpha/beta heterodimeric adhesion glycoprotein receptors that regulate a wide variety of dynamic cellular processes such as cell migration, phagocytosis, and growth and development. X-ray crystallography of the integrin ectodomain revealed its modular architecture and defined its metal-dependent interaction with extracellular ligands. This interaction is regulated from inside the cell (inside-out activation), through the short cytoplasmic alpha and beta integrin tails, which also mediate biochemical and mechanical signals transmitted to the cytoskeleton by the ligand-occupied integrins, effecting major changes in cell shape, behavior, and fate. Recent advances in the structural elucidation of integrins and integrin-binding cytoskeleton proteins are the subjects of this review.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Integrinas
/
Adhesión Celular
/
Subunidades de Proteína
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos