Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.
Cancer Cell
; 12(4): 328-41, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17936558
ABSTRACT
The Polycomb group and oncogene Bmi1 is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic cancer stem cells. Repression of the Ink4a/Arf locus is a well described mechanism through which Bmi1 can exert its proliferative effects. However, we now demonstrate in an orthotopic transplantation model for glioma, a type of cancer harboring cancer stem cells, that Bmi1 is also required for tumor development in an Ink4a/Arf-independent manner. Tumors derived from Bmi1;Ink4a/Arf doubly deficient astrocytes or neural stem cells have a later time of onset and different histological grading. Moreover, in the absence of Ink4a/Arf, Bmi1-deficient cells and tumors display changes in differentiation capacity.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Células Madre
/
Neoplasias Encefálicas
/
Proteínas Nucleares
/
Transducción de Señal
/
Astrocitos
/
Proteínas Proto-Oncogénicas
/
Glioblastoma
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
/
Neuronas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Cancer Cell
Asunto de la revista:
NEOPLASIAS
Año:
2007
Tipo del documento:
Article
País de afiliación:
Países Bajos