Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7.
J Bacteriol
; 190(1): 438-41, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-17981979
ABSTRACT
Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Metiltransferasa de ADN de Sitio Específico (Adenina Especifica)
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Colifagos
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Toxina Shiga II
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Escherichia coli Enterohemorrágica
Idioma:
En
Revista:
J Bacteriol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos